1. Therapy of microangiopathy: Diabetic microangiopathy—diabetic retinopathy, glomerulosclerosis (Kimnel-steil-wilson syndrome); Non-diabetic microangiopathy—sudden microangiopathy; microangiopathy caused by long-term using coumarin derivative cell inhibitors; microangiopathy caused by oral contraceptives, or other drugs; microangiopathy caused by chronic organic diseases (such as hypertension, arteriosclerosis, cirrhosis); 2. Therapy of varicose syndrome: Primary varicose—pain, lumbago, muscle algospasm, paresthesia, acrocyanosis, purpuric dermatitis; Varicosity—chronic venous insufficiency, phlebitis, superficial thrombophlebitis, post-thrombotic syndrome, varicose ulcer, pregnant varicose; 3. Therapy of chronic venous insufficiency accompanied by microcirculatory disorders: Hemorrhoid syndrome; Varicose vein; 4. Adjuvant therapy of venous stripping or phlebosclerosation: Therapy of postoperative syndrome, edema or tissue infiltration.